The layout as it stands now is kinda driven by the basic controls currently in .NET. I don't really plan on deviating much from the controls or layout that's currently implemented. So easy to do, no.
At one point, color saving worked well but when I implemented the new text control, that kinda broke. Fixing it has been difficult, but will definitely work again once I can finish the necessary work involved with being able to save your setup and options.
At this point, I'm not trying to emulate any single type of interface. I've used probably 20 different debugging interfaces/editors over the years, and I've been picking the best features from each. Multiedit is one of the best ones I've ever used for programming (tag recognition/stacked jumping by tag and live searching). Notepad++ is my current favorite free one and my default editor for just about anything I do. However, there's a couple things in notpad++ that aren't as intuitive as they can be (text searching for example). Also the context menu(right mouse click) is missing important stuff by default.
So I do appreciate the input feedback for the interface, but I'm not sure I'll be messing much with the look and feel. I'm more interested in features and whether they have been logically implemented and work correctly. Dockable/hidable tabs is gonna be something I will do at some point. I already started that work with the hidden debug output. I haven't done the tabs yet simply because they are used so much (at least by me) that it really hasn't been required since I'm always warping from tag to tag looking for stuff.
The fun thing about this project for me is that ScriptUO is a tool I actually use on a daily basis, so if something annoys you - chances are it's already annoyed me.