Not really. It's all about what .NET revision you have installed. Since not everyone has .NET 4.0 installed, it can be annoying to try and distribute programs that try and push the envelope. So for ScriptUO, I kept in sync with Razor since that was going to drive the UO crowd within the .NET framework.
Having said that, left to play with things, I wish the OEUO community would think more seriously about using modern .NET in the scripting sphere. Like you're experiencing, it's a joy to use, but Cheffe consistently pisses all over it. Shame really since .NET really solves most of the existing OEUO UI issues.
Cheffe has made it abundantly clear his disdain of the .NET architecture, so I'm not filled with hope for .NET compatibility.
With all that said, I still have fun with .NET daily, and because of that, I make waaay more than 80K/yr.