LOL YEAH!
I've mostly collected console emulators (atari, nintendo, sega, etc) and MAME but I've also crossed the line with my TRS 80, Commodore 64, VIC 20, and Amiga collections.
I've gone pretty old-school with the consoles though: Bally Astrocade, Colecovision, Atari 2600... literally thousands of ROM's! Then, of course, I have the "new stuff" like Sega Genesis, Nintendo 8-Bit, Super Nintendo, Nintendo 64, the handhelds like Game Gear and all of the Nintendo Game Boy versions (Standard, Advanced, Color, etc).
A couple years ago I had a complete MAME set including all NeoGeo's, sound files, ROM's, etc. A friend went to Germany and actually purchased a 10-DVD pack which I quickly copied. Anything from then until now hasn't made it to the collection though but all of my favorites are covered - Mr Do!, Joust, even Dragon's Lair woot! Man, I remember when that hit my local Dream Machine arcade!
XII