Yes, but ocr just means that it needs to be able to see the pixels, a seperate screen works fine, or just leaving the part of your screen open so it can see the plant gump. If it forces the clicks to actually move your mouse, you will need to modify that, as far as I know its not mandatory for it to move the mouse to work. If you are running windows seven I'm pretty sure you can in fact put things in front of the window and it still does the proper ocr, just don't minimize it.