Nope.  A lot of people make the mistake of trying for the best uber artifact drop possible.  I did it by farming for volume.  I'd much rather sell 10x 50M pieces a month than 1x 500M piece a month.  If I have a bad month, I only make 250M.  If someone shooting for the moon has a bad month, they make 0gp.
Mostly, it was jewelry.  I have probably another 200M in low- med-end splinter weapons that were too much trouble to sell.  I'm excellent at pricing jewelry under the new system.  Really crappy at pricing everything else.